24/04/2017 | Coloquios en el CIBION
Agustina Rodríguez Granillo – Viernes 28 de Abril 11:00 hs
MSD

Application of computational modeling in biocatalysis and enzyme design

The incorporation of structural modeling into typical biocatalysis workflows has proven to be crucial to understand enzyme specificity and promiscuity. The next logical step is to use computational modeling to predict enzyme variants that will improve conversion or selectivity, thus reducing the time and screening complexity of traditional directed evolution campaigns. Here, we summarize various examples where computational modeling has been used to explain and predict enzyme activity, as well as to guide the design of improved variants that are relevant from a process perspective. Different enzymes classes will be presented.

Imágenes
cerrar
Últimas entradas
21/08/2018
CIBION-CONICET
13/08/2018
INSTITUTO DE QUÍMICA BIOLÓGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES - IQUIBICEN
07/08/2018
CIBION CONICET
24/07/2018
Departamento de Ciencias Farmacéuticas, Centro Medico de la Universidad de Nebraska, Estados Unidos de América
19/06/2018
Departamento de Física, FCEyN, UBA.